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Quality of life in multiple sclerosis is impacted by daily activity limitations, depression, fatigue, and life satisfaction, not sensorimotor function. This suggests psycho-emotional factors significantly influence well-being in MS patients.

Keywords:
assessmentgaitkinematicsmultiple sclerosisquality of lifesensorimotor

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Area of Science:

  • Neurology
  • Psychology
  • Rehabilitation Science

Background:

  • Multiple Sclerosis (MS) is associated with reduced Quality of Life (QOL).
  • Previous research linked QOL to clinical severity and sensorimotor deficits in MS.
  • The interplay of psychological factors and QOL in MS requires further investigation.

Purpose of the Study:

  • To identify key determinants of QOL in individuals with multiple sclerosis.
  • To explore the impact of depression, fatigue, and life satisfaction on QOL.
  • To assess the relationship between sensorimotor functioning and QOL in MS.

Main Methods:

  • Utilized multiple linear regression models to analyze QOL factors.
  • Assessed QOL using a comprehensive questionnaire.
  • Included end-effector based sensorimotor assessments and evaluated depression, fatigue, and life satisfaction.

Main Results:

  • Everyday life activity limitations were the primary driver of QOL within the questionnaire.
  • No significant association was found between sensorimotor tests and QOL.
  • Depression, fatigue, and satisfaction with life showed significant associations with QOL.

Conclusions:

  • Psycho-emotional coping and adaptability may be dominant determinants of QOL in MS.
  • Current QOL measures may necessitate a reconceptualization for objective assessment in MS.
  • Focusing on psychological well-being alongside physical function is crucial for managing QOL in multiple sclerosis.