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Biological Therapies in Children and Adolescents with Severe Uncontrolled Asthma: A Practical Review

Martina Votto1,2, Maria De Filippo1,2, Amelia Licari1,2

  • 1Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Biologics : Targets & Therapy
|May 13, 2021
PubMed

Insights

Severe asthma in children requires multidisciplinary assessment and targeted therapies. Biological therapies are revolutionizing treatment, offering new hope for managing this complex pediatric condition.

Area of Science:

  • Pediatric Pulmonology
  • Immunology
  • Pharmacology

Background:

  • Severe uncontrolled asthma in children is a complex, heterogeneous condition.
  • Requires multidisciplinary assessment for accurate diagnosis and management.
  • Recent research identifies phenotypes, endotypes, and biomarkers for targeted therapies.

Purpose of the Study:

  • To review current literature on biological therapies for severe asthma in children and adolescents.
  • To highlight advancements in managing pediatric severe asthma.

Main Methods:

  • Literature review of recent research on biological therapies.
  • Focus on epidemiologic, clinical, and molecular mechanisms.
  • Analysis of biomarkers predicting treatment response.

Main Results:

  • Recognition of distinct asthma phenotypes and endotypes.
  • Identification of biomarkers for predicting response to biologic therapies.
  • Introduction of biological therapies has transformed care.

Conclusions:

  • Biological therapies represent a significant advancement in treating severe asthma in pediatric populations.
  • Multidisciplinary care and targeted treatments are crucial for effective management.
  • Ongoing research continues to refine therapeutic strategies.

Keywords:
adolescentsbiological therapychildrenendotypephenotypesevere asthma

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