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New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk
Logan K Townsend1,2, Rebecca E K MacPherson3, David C Wright2
1Department of Medicine, McMaster University, Hamilton, L8S 4L8, Canada.
The Journal of Clinical Endocrinology and Metabolism
|May 13, 2021
Summary
Regular exercise benefits brain health and cognitive function. This review explores how exercise-induced factors, known as exerkines, communicate between the body and brain to promote these positive effects.
Area of Science:
- Neuroscience
- Exercise Physiology
- Aging Research
Background:
- Global population is aging, increasing neurodegenerative disorder prevalence.
- Exercise is known to enhance brain health and cognitive functions.
- Understanding exercise's systemic effects on the brain is crucial.
Purpose of the Study:
- To review exercise-induced brain adaptations.
- To focus on peripheral tissue and brain crosstalk.
- To highlight exercise-induced circulating factors (exerkines).
Main Methods:
- Literature review of recent investigations.
- Focus on exercise-induced circulating factors.
- Examination of exerkine mechanisms in the brain.
Main Results:
- Exercise stimulates the release of various circulating factors (exerkines).
- Key exerkines discussed include irisin, cathepsin B, GPLD1, and ketones.
- These factors mediate exercise's beneficial effects on the brain.
Conclusions:
- Exercise profoundly impacts brain health through systemic signaling.
- Exerkines represent a critical communication pathway between peripheral tissues and the brain.
- Further research into exerkines can inform strategies for combating neurodegeneration.
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