New Horizon: Exercise and a Focus on Tissue-Brain Crosstalk
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Updated: Nov 5, 2025

Application of Passive Head Motion to Generate Defined Accelerations at the Heads of Rodents
Published on: July 21, 2022
Logan K Townsend1,2, Rebecca E K MacPherson3, David C Wright2
1Department of Medicine, McMaster University, Hamilton, L8S 4L8, Canada.
Abstract:
The world population is aging, leading to increased rates of neurodegenerative disorders. Exercise has countless health benefits and has consistently been shown to improve brain health and cognitive function. The purpose of this review is to provide an overview of exercise-induced adaptations in the brain with a focus on crosstalk between peripheral tissues and the brain. We highlight recent investigations into exercise-induced circulating factors, or exerkines, including irisin, cathepsin B, GPLD1, and ketones and the mechanisms mediating their effects in the brain.
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