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[A new lignan from Euscaphis konishii].

Jing-Xin Chen1, Lin Ni2, Yao Zhang1

  • 1College of Plant Protection, Fujian Agriculture and Forestry University Fuzhou 350002, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|May 13, 2021
PubMed
Summary
This summary is machine-generated.

Researchers investigated Euscaphis konishii twigs for anti-hepatoma compounds. Two lignans, 4-ketopinoresinol and vladinol D, showed moderate inhibitory activity against HepG2 liver cancer cells.

Keywords:
Euscaphis konishiianti-hepatomachemical constituentkonilignanlignans

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Organic Chemistry

Background:

  • Hepatoma, a primary liver cancer, presents a significant global health challenge.
  • Natural products are a vital source for discovering novel anti-cancer therapeutics.
  • Euscaphis konishii is a plant species with potential medicinal properties.

Purpose of the Study:

  • To isolate and identify chemical constituents from Euscaphis konishii twigs.
  • To evaluate the anti-hepatoma activity of the isolated compounds.
  • To discover new lignans with potential therapeutic applications.

Main Methods:

  • Extraction of Euscaphis konishii twigs.
  • Purification using silica gel, Sephadex LH-20, and preparative-HPLC.
  • Structure elucidation via spectroscopic methods (NMR, MS).
  • In vitro anti-proliferative assays using HepG2 cells.

Main Results:

  • Twelve compounds were isolated, including a new lignan (konilignan).
  • Compounds 4-ketopinoresinol and vladinol D exhibited moderate inhibitory effects on HepG2 cells.
  • IC50 values were determined for the active compounds: 107.12 μmol·L−1 for 4-ketopinoresinol and 183.56 μmol·L−1 for vladinol D.

Conclusions:

  • Euscaphis konishii contains diverse lignans with potential anti-hepatoma properties.
  • 4-ketopinoresinol and vladinol D warrant further investigation as lead compounds for liver cancer therapy.
  • The study contributes to the understanding of Euscaphis konishii phytochemistry and its medicinal potential.