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The value of adding a single co-test in HPV primary screening
Lina Jans1, Karin Zetterström1, Lovisa Bergengren1
1Department of Women's Health, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Preventive Medicine
|May 13, 2021
Summary
Adding co-testing to HPV screening for cervical cancer in women aged 41-45 found few additional high-grade dysplasias. The clinical significance of these HPV-negative cases remains unclear.
Area of Science:
- Gynecology
- Oncology
- Public Health
Background:
- Sweden's cervical cancer screening recommends HPV testing for women over 30.
- Co-testing (HPV and cytology) is advised for the first screening after age 40.
Purpose of the Study:
- To evaluate the yield of HPV-negative cervical dysplasia in women aged 41-45.
- To assess the value of adding co-testing to HPV-based screening programs.
Main Methods:
- Retrospective study of abnormal cytology results in women aged 41-45 (2012-2016).
- Analysis of HPV status in abnormal cytology samples within the Örebro County screening program.
Main Results:
- Out of 10,511 women, 468 had abnormal cytology; 255 were HPV-negative.
- Most HPV-negative cases showed normal cytology on follow-up.
- Only four HPV-negative cases had high-grade dysplasia (CIN2); no adenocarcinoma in situ or invasive cancer found.
Conclusions:
- Adding a single co-test to HPV screening identified few additional high-grade cervical dysplasias.
- The clinical significance of these few HPV-negative, high-grade dysplasia cases is uncertain.
Keywords:
Cervical intraepithelial neoplasiaEarly detection of cancerHuman papillomavirusScreeningUterine cervical neoplasmsMore Related Videos
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