The Formidable yet Unresolved Interplay between Endometriosis and Obesity

Area of Science:

• Reproductive biology
• Metabolic disorders
• Genetics

Background:

• Obesity and endometriosis are prevalent conditions with an unclear relationship.
• Observational studies suggest an inverse correlation between endometriosis and low body mass index (BMI).
• However, obesity may not be protective and could exacerbate endometriosis severity.

Purpose of the Study:

• To explore the intricate relationship between obesity and endometriosis.
• To investigate anthropometric traits, early-life BMI effects, and genetic factors.
• To identify potential biomolecules involved in the pathophysiology.

Main Methods:

• Review of observational studies correlating BMI and endometriosis.
• Analysis of studies on anthropometric traits and early-life BMI.
• Examination of genetic associations and biomolecules emerging from bariatric surgery research.
• Focus on angiogenesis and inflammation pathways.

Main Results:

• An inverse correlation between endometriosis and low BMI is repeatedly observed.
• Obesity does not protect against endometriosis; increased BMI may correlate with more severe disease.
• Genetic factors and specific polymorphisms may link endometriosis and increased BMI.
• Biomolecules related to angiogenesis and inflammation are emerging as key players.

Conclusions:

• The relationship between obesity and endometriosis is complex and multifactorial.
• Further research is needed to elucidate genetic backgrounds and identify obesity-related biomarkers.
• Metabolic bariatric surgery research offers insights into pathophysiological interactions.
• Future studies should focus on experimental models, registries, and multidisciplinary collaboration.