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Myasthenia Gravis Revealing Hodgkin's Lymphoma
Jaouad Yousfi1, Fatimazahra Bensalek1, Mouna Zahlane1
1University Hospital of Mohammed VI, Department of Internal Medicine, Marrakesh, Morocco.
Introduction:
Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction.
Patient And Methods:
We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma.
Results:
A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ≤0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin's lymphoma.
Conclusion:
The association of lymphomas with myasthenia gravis has been rarely reported.
Learning Points:
Myasthenia gravis is an autoimmune disease of the neuromuscular junction and can be associated with malignant haemopathy.The coexistence of myasthenia and Hodgkin's lymphoma is very rare.This association is a therapeutic challenge.
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