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What's new in chronic pain pathophysiology

Ivan Cohen1, Mark J Lema1

  • 1Department of Anesthesiology, Jacobs School of Medicine, SUNY University at Buffalo and Biomedical Sciences, Buffalo, New York, USA.

Canadian Journal of Pain = Revue Canadienne De La Douleur
|May 14, 2021
PubMed

Insights

New pain management strategies are emerging, focusing on nerve growth factor antagonists, microglial modulation, AMP-activated protein kinase activators, and genetic pain factors for targeted therapies.

Area of Science:

  • Pain research
  • Neuroscience
  • Pharmacology

Background:

  • Pain pathophysiology understanding is evolving.
  • Cellular and subcellular pathways offer targeted therapy opportunities.
  • Current pain management often lacks direct pathway targeting.

Purpose of the Study:

  • To update knowledge on four developing areas in pain management.
  • To highlight novel targets for preventing, treating, and modifying pain.
  • To bridge current practices with future therapeutic advancements.

Main Methods:

  • Review of emerging research in nerve growth factor antagonists.
  • Analysis of microglial modulation strategies.
  • Exploration of AMP-activated protein kinase activators.
  • Investigation of genetic pain factors.

Main Results:

  • Nerve growth factor antagonists show therapeutic potential.
  • Microglial modulation offers new avenues for pain control.
  • AMP-activated protein kinase activators present novel treatment options.
  • Genetic factors are increasingly recognized in pain conditions.

Conclusions:

  • These four areas represent novel targets for targeted pain therapies.
  • Advancements suggest future availability of therapies targeting these pathways.
  • The field is progressing towards effective interventions for acute, chronic, and neuropathic pain.
Keywords:
AMPKgeneticsmicroglianerve growth factorpain pathophysiology

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