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Related Experiment Video

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Fabrication of Silica Ultra High Quality Factor Microresonators
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Monodisperse and size-tunable high-quality factor microsphere biolasers.

Toan Van Nguyen, Trung Duc Nguyen, Nhat Van Pham

    Optics Letters
    |May 14, 2021
    PubMed
    Summary

    We developed a new microfluidic method to create tunable, monodisperse protein microsphere biolasers. This technique enables mass production of high-quality biolasers for biosensing and medical applications.

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    Area of Science:

    • Optics
    • Biotechnology
    • Materials Science

    Background:

    • Microsphere biolasers show promise for biosensing and cell tracking.
    • Existing fabrication methods lack reproducibility and tunability.

    Purpose of the Study:

    • To develop a novel microfluidic fabrication technique for producing nearly monodisperse, dye-doped protein microsphere biolasers.
    • To demonstrate tunable size control and high reproducibility of the fabricated microsphere biolasers.

    Main Methods:

    • Utilized a microfluidic-based approach for fabricating protein microspheres.
    • Incorporated dye-doping for laser emission.
    • Characterized microsphere size, lasing properties (threshold, Q-factor), and reproducibility.

    Main Results:

    • Achieved tunable microsphere sizes ranging from 50 to 150 µm.
    • Demonstrated high monodispersity, with ~70% of 85 µm beads having the same size.
    • Observed whispering gallery mode lasing with a low threshold (7 µJ/mm²) and high Q-factor (up to 3000).
    • Showcased similar lasing characteristics for microspheres of the same size, indicating high reproducibility.

    Conclusions:

    • The microfluidic fabrication technique offers an effective method for mass production of high-Q factor microsphere biolasers.
    • This advancement is a significant step towards practical biosensing and medical applications.