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Impacts of circulating microRNAs in exercise-induced vascular remodeling
Gary P Van Guilder1, Claudia C Preston2, Thayne A Munce3,4
1Vascular Protection Research Laboratory, Exercise & Sport Science Department, Western Colorado University, Gunnison, Colorado.
Summary
Novel biomarkers like cell-free microRNAs offer insights into cardiovascular adaptation from athletic training. These circulating molecules aid in understanding physiological remodeling and can serve as diagnostic tools for trained versus untrained states.
Area of Science:
- Sports genomics and cardiovascular physiology.
- Molecular biology and exercise science.
Background:
- Cardiovascular adaptation is central to athletic training.
- Circulating biomarkers are crucial for monitoring cardiovascular function.
- Next-generation technologies enable precise analysis of molecular signatures.
Purpose of the Study:
- To review the emerging field of sports/performance genomics.
- To focus on microRNAs as diagnostic and prognostic tools.
- To discuss athletic vascular remodeling in the context of microRNAs.
Main Methods:
- Overview of current knowledge on sports genomics and microRNAs.
- Exploration of cell-free microRNAs in peripheral circulation.
- Application of molecular and bioinformatic approaches.
Main Results:
- Cell-free DNA and RNA are emerging biomarkers for cardiovascular function.
- MicroRNAs exhibit pleiotropic effects and tissue-specific roles.
- Circulating microRNAs represent a distal signaling mechanism.
Conclusions:
- MicroRNAs are promising functional diagnostic and prognostic tools in sports science.
- Understanding athletic vascular remodeling is enhanced by studying microRNAs.
- Future research should explore systems biology for exercise-induced physiology and pathology.
