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Eduardo Salazar-Martínez1, José Ángel Hernández-Mariano2, Marcia Galván-Portillo3

  • 1Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México. esalazar@insp.mx.

Salud Publica De Mexico
|May 14, 2021
PubMed
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SARS-CoV-2 infection can cause significant kidney damage, including chronic kidney disease (CKD) and acute kidney injury (AKI). Monitoring kidney function is crucial for improving outcomes in hospitalized patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • SARS-CoV-2 infection has been associated with various organ complications.
  • Kidney damage is a recognized but not fully understood complication of COVID-19.

Purpose of the Study:

  • To summarize the scientific evidence on renal alterations linked to SARS-CoV-2 infection.
  • To assess the impact of pre-existing and acute kidney injury on COVID-19 prognosis.

Main Methods:

  • A rapid review was conducted using Cochrane methodology.
  • Systematic search and synthesis of existing scientific literature.

Main Results:

  • Prevalence of pre-existing chronic kidney disease (CKD) in SARS-CoV-2 patients ranged from 1% to 38%.

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  • Acute kidney injury (AKI) incidence varied widely, from 2.9% to 86.4%.
  • Patients with CKD or developing AKI had a worse prognosis, with a higher risk of death (RR=1.49).

    • Conclusions:

    • Permanent evaluation and monitoring of renal reserve are vital for hospitalized SARS-CoV-2 patients.
    • This monitoring can improve outcomes for patients with pre-existing CKD and those without CKD who develop AKI.
    • Serum creatinine is a key marker for assessing renal reserve in severe and fatal COVID-19 cases.