Readmission after hospitalization with Staphylococcus aureus bacteremia in children
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Published on: February 9, 2011
Kengo Inagaki1, Md Abu Yusuf Ansari2, Charlotte V Hobbs3
1Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA; Department of Population Health Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Insights
Staphylococcus aureus bacteremia in children leads to high readmission rates, especially with catheter-related infections. This condition and subsequent readmissions incur significant healthcare costs, necessitating further research for improved pediatric outcomes.
Area of Science:
- Pediatric Infectious Diseases
- Healthcare Quality Improvement
- Epidemiology
Background:
- Readmission rates are critical indicators of healthcare quality.
- Further research is needed on Staphylococcus aureus bacteremia readmissions in pediatric populations.
Purpose of the Study:
- To investigate the incidence and predictors of non-elective readmission in children hospitalized with Staphylococcus aureus bacteremia.
- To analyze the associated healthcare costs of initial hospitalization and readmission.
Main Methods:
- Population-based longitudinal observational study using inpatient data (2009-2015).
- Inclusion criteria: children (≤18 years) hospitalized with S. aureus bacteremia.
- Cox proportional hazards regression models used to assess non-elective readmission outcomes.
Main Results:
- 18.0% and 28.3% of 1240 children experienced readmission within 30 and 90 days, respectively.
- Catheter-related infections were significantly associated with 30-day readmission (HR: 1.79, 95% CI: 1.31-2.45).
- Median costs: $29,914 for initial hospitalization and $10,956 for 30-day readmission.
Conclusions:
- Staphylococcus aureus bacteremia is linked to substantial pediatric readmission rates.
- Catheter-related infections are a key risk factor for readmission.
- High costs associated with S. aureus bacteremia hospitalization and readmission underscore the need for intervention research.
Background:
Readmission rate is an important quality measure and can inform patient care. However, readmission of S. aureus bacteremia in children requires further research.
Methods:
We performed a population-based longitudinal observational study using the State Inpatient Database from New York, Florida, and Washington, 2009-2015. Children aged 18 years or younger hospitalized with S. aureus bacteremia were included. The outcome of non-elective readmission was assessed by developing Cox proportional hazards regression models.
Results:
Of 1240 children with S. aureus bacteremia, 223 (18.0%) and 351 (28.3%) had non-elective readmission within 30 days and 90 days after discharge, respectively. On multivariable analysis, catheter related infection (hazard ratio, HR: 1.79, 95% confidence interval, CI: 1.31-2.45) was associated with 30-day readmission. The median cost of the original hospitalization for S. aureus bacteremia was $29 914 (interquartile range, IQR: $13 276-$71 284), and that of 30 day readmission was $10 956 (IQR: $5765-$24 753).
Conclusions:
S. aureus bacteremia is associated with a high rate of readmission in children, particularly in those with catheter related infection. Hospitalization with S. aureus bacteremia and readmission are costly. Future research should seek interventions to improve outcomes of S. aureus bacteremia in children, and the results of this study can serve as a benchmark.
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