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Related Experiment Video

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Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Published on: August 10, 2016

Formulation of ionic liquid APIs via spray drying processes to enable conversion into single and two-phase solid

Evangelia Tsolaki¹, Michael W Stocker², Anne Marie Healy³

¹School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4, Ireland; SSPC, The SFI Research Centre for Pharmaceuticals, School of Chemical and Bioprocess Engineering, University College Dublin, Dublin 4, Ireland; EPSRC-SFI Centre for Doctoral Training in Transformative Pharmaceutical Technologies, Ireland.

International Journal of Pharmaceutics

|May 14, 2021

Summary

This summary is machine-generated.

Ionic liquid (IL) drug forms can be solidified into stable solid dosage forms using spray encapsulation or polymer miscibility. These novel methods improve the manufacturability of poorly soluble drugs for oral solid dosage (OSD) applications.

Keywords:

Co-processed APIs Ionic liquid APIs Solid dispersions Spray drying Spray encapsulation

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Published on: August 9, 2022

Area of Science:

Pharmaceutical Science
Materials Science
Drug Delivery

Background:

Ionic liquids (ILs) offer solutions for poorly water-soluble drugs and enhance drug stability.
Challenges in handling and manufacturing ILs of active pharmaceutical ingredients (APIs) hinder their use in oral solid dosage forms (OSDs).

Purpose of the Study:

To demonstrate the applicability of spray encapsulation for solidifying diverse low glass transition temperature (Tg) API-ILs.
To explore a novel polymer-API-IL miscibility approach for API-IL solidification.
To overcome the glass transition temperature (Tg) suppression in room temperature ILs for OSD applications.

Main Methods:

Spray encapsulation using an immiscible polymer (ethyl cellulose) for phase-separated systems.
Spray drying utilizing polymer-API-IL miscibility with a high Tg polymer (maltodextrin) for amorphous solid dispersions (ASDs).
Characterization using modulated differential scanning calorimetry (mDSC) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR).

Main Results:

Successfully produced spray-dried solid materials from low Tg API-ILs at acceptable loadings and yields for OSDs.
Demonstrated two solidification approaches: phase-encapsulated systems and amorphous solid dispersions (ASDs).
Both methods effectively addressed the Tg suppression associated with room temperature ILs.

Conclusions:

The study presents two viable methods for solidifying API-ILs, broadening their application in OSDs.
This work lays the foundation for a mechanistic design approach by understanding critical physical attributes of API-IL systems.
The findings facilitate the development of advanced drug delivery systems for challenging pharmaceutical compounds.