Related Experiment Video
Updated: May 31, 2026
15:24
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
Published on: December 16, 2022
Recognizing NIH's Role in Turning Discoveries into Cancer Treatments
Berna Uygur1, Steven Ferguson2
1Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
LES Nouvelles. Licensing Executives Society (U.S.A.)
|May 29, 2026
Summary
The National Institutes of Health (NIH) significantly advanced cancer research and public health through therapeutic development, especially via the National Cancer Institute (NCI). Their contributions have saved lives since the 1960s.
Area of Science:
- Biomedical Research
- Public Health Initiatives
- Cancer Therapeutics
Background:
- The National Institutes of Health (NIH), established in 1887, has a long history of driving life science innovation.
- The National Cancer Institute (NCI) plays a pivotal role within the NIH, focusing on cancer research and treatment.
- Technology transfer from research institutions to clinical application is crucial for public health advancements.
Purpose of the Study:
- To explore the NIH's role, particularly the NCI's, in cancer therapeutic development.
- To evaluate the NIH's technology transfer contributions in major cancer types.
- To assess the impact of NIH-supported cancer research on public health outcomes.
Main Methods:
- Analysis of publicly available data on NIH and NCI activities.
- Focus on therapeutic development and technology transfer.
- Case studies examining breast, lung, and prostate cancer.
Main Results:
- The NIH, led by the NCI, has provided strong support for cancer research.
- Significant contributions to cancer therapeutic development have been identified.
- Evidence suggests substantial improvements in public health and life-saving interventions since the 1960s.
Conclusions:
- The NIH and NCI have been instrumental in advancing cancer research and treatment.
- NIH's technology transfer efforts have demonstrably improved public health.
- The impact of NIH-supported cancer research is substantial, leading to saved lives.
Related Concept Videos
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...