Related Experiment Video

Updated: Aug 23, 2026

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus
10:21

In Vivo Imaging Systems IVIS Detection of a Neuro-Invasive Encephalitic Virus

Published on: December 2, 2012

21.1K

Two Cases of Cronobacter Sakazakii Meningitis in Infants: The Importance Of Early Advanced Brain Imaging and Public

Margaret G Taylor1, Megan H Amerson-Brown2, Kristina Hulten1

  • 1From the Section of Infectious Diseases, Department of Pediatrics.

The Pediatric Infectious Disease Journal
|May 15, 2021
PubMed

Insights

Two infants contracted Cronobacter sakazakii meningitis from powdered infant formula. Early brain imaging and public health reporting are crucial for managing this serious infant infection.

Area of Science:

  • Neonatal infectious diseases
  • Pediatric neurology
  • Microbiology

Background:

  • Cronobacter sakazakii is a rare but serious pathogen causing meningitis in infants.
  • Powdered infant formula has been identified as a potential source of Cronobacter sakazakii infection.
  • Neonatal meningitis requires prompt diagnosis and management to prevent severe complications.

Observation:

  • Two infants were hospitalized with confirmed Cronobacter sakazakii meningitis.
  • Both infants had documented exposure to powdered infant formula in their home environment.
  • One infant experienced a subdural empyema requiring surgical drainage.

Findings:

  • Both infants survived the initial meningitis episode.
  • One infant developed permanent left sensorineural hearing loss as a sequela.
  • C. sakazakii meningitis can lead to significant neurological deficits.

Implications:

  • Early advanced neuroimaging, such as MRI or CT scans, is recommended for infants diagnosed with C. sakazakii meningitis.
  • Prompt reporting of C. sakazakii infections to public health authorities is essential for outbreak detection and control.
  • This case series highlights the persistent risk associated with contaminated powdered infant formula and the importance of vigilant surveillance.

More Related Videos

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

20.0K
Listeria monocytogenes Infection of the Brain05:02

Listeria monocytogenes Infection of the Brain

Published on: October 2, 2018

13.0K

Related Concept Videos

Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...