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Ankylosing Spondylitis and Risk of Cardiac Arrhythmia and Conduction Disorders: A Systematic Review and Meta-analysis
Negar Morovatdar1, Gerald F Watts2, Yones Bondarsahebi3
1Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Current Cardiology Reviews
|May 16, 2021
Summary
Ankylosing spondylitis (AS) is linked to a higher risk of atrial fibrillation and atrioventricular block. This meta-analysis supports an association between AS and these cardiac conduction abnormalities.
Area of Science:
- Cardiology
- Rheumatology
- Epidemiology
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton.
- The association between AS and cardiovascular complications, particularly heart conduction disorders and arrhythmias, requires further investigation.
Approach:
- A systematic review and meta-analysis of observational studies was conducted using PubMed, Embase, and Web of Science.
- Seven studies were included, analyzing data on atrial fibrillation, atrioventricular block, and other conduction abnormalities in AS patients.
- Random- and fixed-effects models were employed to pool results, with subgroup analysis based on study design.
Key Points:
- AS patients demonstrated an increased risk of atrial fibrillation (RR: 1.85) and atrioventricular block (OR: 3.46) compared to the general population.
- Cohort studies revealed a stronger association between AS and atrioventricular block (RR: 5.14) than cross-sectional studies.
- No significant association was found between AS and any arrhythmia or general conduction disorders.
Conclusions:
- The findings support a significant association between ankylosing spondylitis and an elevated risk of developing atrial fibrillation and atrioventricular block.
- These results highlight the importance of cardiovascular monitoring in patients diagnosed with AS.
Keywords:
Ankylosing spondylitisarrhythmiacardiovascular diseasemeta-analysis.rheumatologysystematic reviewMore Related Videos
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