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Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone

Monica Caliber1, Farid Saad2

  • 1American Medical Writers Association (AMWA), Rockville, MD, USA; International Society for Medical Publication Professionals (ISMPP), Fort Lauderdale, FL, USA.

Current Opinion in Pharmacology
|May 16, 2021
PubMed

Insights

Testosterone therapy (TTh) in men with obesity or type 2 diabetes (T2D) aids fat loss, muscle gain, and reduces T2D risk. TTh improves sexual function and well-being beyond lifestyle changes.

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Men's Health

Background:

  • Obesity and type 2 diabetes (T2D) are prevalent in men with testosterone deficiency (TD).
  • A cyclical relationship exists between TD, obesity, T2D, and worsening metabolic health.
  • Testosterone deficiency (TD) increases the risk of obesity and type 2 diabetes (T2D).

Purpose of the Study:

  • To evaluate the effects of testosterone therapy (TTh) on body composition, T2D risk, and glycemic control in men.
  • To assess the impact of TTh on sexual function and overall well-being.

Main Methods:

  • The study involved a large-scale, randomized controlled trial named the 'testosterone for diabetes mellitus' trial.
  • Participants received testosterone therapy (TTh) over a 2-year period.
  • Outcomes measured included body fat mass, muscle mass, incidence of T2D, glycemic control, sexual function, and well-being.

Main Results:

  • Testosterone therapy (TTh) led to significant fat loss and increased muscle mass.
  • TTh significantly reduced the risk of developing type 2 diabetes (T2D) over 2 years.
  • TTh demonstrated potential to reverse existing T2D and improve sexual function and well-being.

Conclusions:

  • Testosterone therapy (TTh) offers significant benefits for men with obesity and/or T2D, including improved body composition and reduced T2D risk.
  • TTh may be a valuable therapeutic option for managing metabolic dysfunction and improving quality of life in affected men.
  • The findings suggest TTh's efficacy extends beyond lifestyle interventions alone for improving health outcomes.

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