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[Tumor necrosis factor alfa in very elderly patients with coronary artery disease.]

S V Topolyanskaya1, T A Eliseeva2, O N Vakulenko2

  • 1I.M.Sechenov First Moscow State Medical University, 8 build. 2 Trubetskaya str., Moscow 119991, Russian Federation,

Advances in Gerontology = Uspekhi Gerontologii
|May 16, 2021
PubMed

Insights

Tumor necrosis factor-alpha (TNF-α) levels are elevated in very elderly patients with coronary artery disease (CAD). Higher TNF-α correlates with heart failure, hyperuricemia, and kidney function markers, but decreases with age.

Area of Science:

  • Cardiology
  • Immunology
  • Geriatrics

Background:

  • Coronary artery disease (CAD) is prevalent in the very elderly.
  • Tumor necrosis factor-alpha (TNF-α), a pro-inflammatory cytokine, plays a role in cardiovascular pathology.
  • Understanding TNF-α's role in elderly CAD patients is crucial for targeted therapies.

Purpose of the Study:

  • To investigate TNF-α concentrations in very elderly patients with CAD.
  • To explore the relationship between TNF-α and pathological conditions in this demographic.
  • To compare TNF-α levels in CAD patients versus a control group.

Main Methods:

  • Comparative study design.
  • Measurement of serum TNF-α concentrations.
  • Correlation analysis with clinical parameters (uric acid, β-Cross Laps, creatinine, urea, HDL-cholesterol, leptin).

Main Results:

  • Elevated average TNF-α levels (10+4.9 pg/ml) in CAD patients compared to controls (6.1+1.8 pg/ml).
  • Increased TNF-α associated with chronic heart failure and hyperuricemia.
  • Positive correlations found between TNF-α and uric acid, β-Cross Laps, creatinine, and urea.
  • Negative correlations observed with HDL-cholesterol and leptin.
  • TNF-α concentration decreased with advancing age.

Conclusions:

  • Elevated TNF-α is a significant finding in very elderly patients with CAD.
  • TNF-α is linked to key comorbidities and biomarkers in this population.
  • Age-related decline in TNF-α warrants further investigation in the context of cardiovascular health.

Keywords:
coronary artery diseaseold agetumor necrosis factor-alfa (TNF-α)

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