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[Relationships between body composition and hematological parameters in long-living patients with coronary artery
S V Topolyanskaya1,2, T A Eliseeva2, A I Sanina2
1I.M.Sechenov First Moscow State Medical University, 8 build. 2 Trubetskaya str., Moscow 119991, Russian Federation,
Insights
Hematological parameters and body composition are linked in elderly patients with coronary artery disease. Lower bone density and anemia correlate with reduced hemoglobin, while obesity shows higher blood counts.
Area of Science:
- Gerontology and Cardiovascular Medicine
- Hematology and Body Composition Analysis
Context:
- Investigates hematological parameters in centenarians (≥90 years) diagnosed with coronary artery disease (CAD).
- Focuses on the interplay between hematological indicators and body composition in an aging population with cardiovascular conditions.
Purpose:
- To explore the relationships between hematological parameters and body composition in elderly patients with CAD.
- To identify correlations between specific blood components (hemoglobin, iron, erythrocytes, leukocytes, platelets) and body composition metrics (bone mineral density, lean tissue mass, fat tissue mass).
Summary:
- A cross-sectional study of 239 centenarians with CAD revealed significant associations between hematological markers and body composition.
- Anemia (45.2%) was common. Lower bone mineral density correlated with reduced hemoglobin. Osteoporosis was linked to lower hemoglobin and iron levels.
- Higher hemoglobin, erythrocytes, leukocytes, lymphocytes, and monocytes were observed in obese patients. Platelets correlated positively with fat mass and inversely with lean mass.
Impact:
- Highlights the complex relationship between hematological status and body composition in the very old with CAD.
- Suggests potential for integrated assessment of blood parameters and body composition for managing elderly CAD patients.
- Provides insights into the physiological adaptations and health status of centenarians with cardiovascular disease.
Abstract:
The study objective to investigate hematological parameters and determine the relationships between these indicators and body composition in centenarians with coronary artery disease. This work is a cross-sectional study, which enrolled 239 patients over 90 years old hospitalized with a diagnosis of coronary artery disease; most of them (67,8%) were women. The age of the patients ranged from 90 to 106 years, averaging 92,8 (±2,5) years. Body composition was analyzed by dual energy X-ray absorptiometry. Anemia was detected in 108 (45,2%) patients, while a significant direct correlation was found between the hemoglobin level and all indicators of bone mineral density (p=0,004-0,00002). Patients with osteoporosis had lower levels of hemoglobin (p=0,002) and blood iron (p=0,02). Direct correlations were established between the hemoglobin level and lean tissue mass (p=0,06-0,003). Patients with obesity had higher levels of hemoglobin (p=0,007), erythrocytes (p=0,03), leukocytes (p=0,04), lymphocytes (p=0,01) and monocytes (p=0,05). A direct correlation was registered between the platelets count and fat tissue mass (p=0,04-0,00006) along with an inverse correlation between platelets and lean tissue (p=0,001-0,0004). The study results indicate significant relationships between the parameters of body composition and hematological indicators.
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