Related Experiment Video

Updated: Nov 5, 2025

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

811

[Significance of platelets in inflammatory and thrombotic reactions in the elderly.]

A M Osadchuk1, I L Davydkin1, I A Zolotovskaia1

  • 1Samara State Medical University, 89 Chapaevskaya str., Samara 443099, Russian Federation,

Advances in Gerontology = Uspekhi Gerontologii
|May 16, 2021
PubMed

Insights

Aging platelets contribute to dangerous blood clots in elderly patients with cardiovascular disease and COVID-19. Understanding platelet aging and aggregation is key for early antiplatelet therapy.

Area of Science:

  • Gerontology
  • Hematology
  • Infectious Diseases

Background:

  • Thrombotic reactions are a significant concern in the elderly, particularly with cardiovascular diseases.
  • New data is emerging on hemostatic system changes, including platelet and plasma levels, in patients with COVID-19.

Purpose of the Study:

  • To review pathophysiological platelet reactions during aging.
  • To explore mechanisms of pathological platelet aggregation.
  • To inform discussions on early antiplatelet therapy for cardiovascular diseases and COVID-19.

Main Methods:

  • Literature review of fundamental and clinical data.
  • Synthesis of information on platelet aging and aggregation.
  • Analysis of hemostatic system changes in COVID-19 patients.

Main Results:

  • Platelet aging is associated with thrombotic reactions.
  • Pathological aggregation mechanisms in aging platelets are being elucidated.
  • COVID-19 impacts the hemostatic system, involving platelets.

Conclusions:

  • Understanding platelet aging and aggregation is crucial for managing thrombotic risks.
  • Early antiplatelet therapy may be beneficial for cardiovascular patients and those with COVID-19.
  • Further research is needed to fully understand platelet roles in COVID-19 and aging.

Keywords:
COVID-19aginginflammationplateletsthrombotic complications

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