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Updated: Nov 5, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
Published on: June 18, 2021
Acute micro-thrombosis after subarachnoid hemorrhage: A new therapeutic target?
Fenghui Ye1, Richard F Keep1, Ya Hua1
1Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Abstract:
Microthrombi formation in the brain following subarachnoid hemorrhage (SAH) has been recognized and suspected to contribute to cerebral ischemia. A recent study found that ultra-early cerebral micro-thrombosis occured four hours after experimental SAH. The number of thrombotic microvessels correlated with brain-blood barrier disruption and neuronal injury. If acute cerebral micro-thrombi also occur in humans, is it time to develop a therapy with systemic thrombolysis for SAH patients?
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