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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

383
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
383

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Updated: Nov 5, 2025

Scaffold-supported Transplantation of Islets in the Epididymal Fat Pad of Diabetic Mice
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Acute pancreatitis-induced islet dysfunction in ferrets.

Yaling Yi1, Xingshen Sun1, Bo Liang1

  • 1Department of Anatomy and Cell Biology, Iowa City, IA, USA.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|May 17, 2021
PubMed
Summary
This summary is machine-generated.

Acute pancreatitis in ferrets causes hyperglycemia due to temporary islet cell dysfunction and insulin resistance. This new animal model helps study glucose metabolism during acute pancreatitis.

Keywords:
GlucagonGlucose intoleranceIncretinsInsulinPancreatitis

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Animal Models

Background:

  • Hyperglycemia pathogenesis in acute pancreatitis (AP) is poorly understood.
  • Lack of suitable animal models and human tissue accessibility hinders research.
  • Developing an AP animal model is crucial for mechanistic studies.

Purpose of the Study:

  • To establish a ferret model of acute pancreatitis.
  • To investigate the mechanisms of hyperglycemia and impaired glucose tolerance in AP.
  • To utilize the model for understanding AP-related metabolic disturbances.

Main Methods:

  • Ferrets received cerulein injections to induce mild AP.
  • Collected blood for glucose, inflammatory markers, and hormones (insulin, glucagon, GLP-1, GIP).
  • Performed glucose and mixed meal tolerance tests; analyzed pancreatic histology.

Main Results:

  • Cerulein induced AP with hyperglycemia, elevated inflammatory markers, and altered hormone levels (lower insulin).
  • Impaired glucose tolerance and insulin resistance were observed.
  • Metabolic abnormalities resolved within 3 months, indicating transient islet cell dysfunction.

Conclusions:

  • Cerulein-induced AP in ferrets effectively models hyperglycemia.
  • The model demonstrates transient islet cell dysfunction and insulin resistance.
  • This ferret model offers a valuable tool for studying AP-related hyperglycemia.