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Stefan Josef Hammerschmidt1, Patrick Müller1, Tanja Schirmeister1

  • 1Institut für Pharmazeutische und Biomedizinische Wissenschaften (IPBW), Johannes Gutenberg-Universität Mainz, Staudinger Weg 5, D-55128 Mainz, Deutschland.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|May 17, 2021
PubMed
Summary
This summary is machine-generated.

We identified isoindolines as a novel class of SARS-CoV papain-like protease (PLpro) inhibitors. Understanding their structure-activity relationship is key for developing new antiviral drugs targeting viral replication.

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Area of Science:

  • Virology
  • Medicinal Chemistry
  • Drug Discovery