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Uric acid is associated with cardiac death in patients with hypertrophic obstructive cardiomyopathy

Jun Gao1, Chun-Li Shao2, Xiang-Bin Meng3

  • 1Heart Center, the First Hospital of Hebei Medical University, Shijiazhuang, China.

Journal of Geriatric Cardiology : JGC
|May 17, 2021
PubMed

Insights

High uric acid (UA) levels are linked to increased cardiac death risk in hypertrophic obstructive cardiomyopathy (HOCM) patients. Lowering UA may improve survival in these individuals.

Area of Science:

  • Cardiology
  • Biochemistry
  • Clinical Medicine

Background:

  • The prognostic significance of uric acid (UA) in hypertrophic obstructive cardiomyopathy (HOCM) remains under-investigated.
  • This study evaluates UA as an independent predictor of cardiac mortality in HOCM patients.

Purpose of the Study:

  • To determine if uric acid levels are an independent risk factor for cardiac death in patients with HOCM.
  • To analyze the association between different uric acid tertiles and cardiac death events.

Main Methods:

  • A cohort of 317 HOCM patients undergoing conservative treatment was analyzed.
  • Patients were stratified into three groups based on uric acid levels (Tertile 1, 2, and 3).
  • Cardiac death events were tracked over a median follow-up of 45 months.

Main Results:

  • Cardiac death occurred in 9.1% of patients, with significantly higher rates in the highest UA tertile (Tertile 3).
  • Uric acid level was a significant independent risk factor for cardiac death in multivariate analysis.
  • The highest UA tertile showed a significantly higher risk of cardiac death compared to the lowest tertile.

Conclusions:

  • Elevated uric acid concentration is independently associated with cardiac death in HOCM patients on conservative treatment.
  • Further research, including randomized trials of UA-lowering agents, is recommended for HOCM management.
Abstract

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