Related Experiment Video
Updated: Nov 5, 2025
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
3.2K
Lupus-Mediated Kidney Damage: Lupus Nephritis or Collapsing Glomerulopathy?
Angel De La Cruz1, Haider Ghazanfar1, Nayrobi Peña1
1Internal Medicine, BronxCare Health System, Bronx, USA.
Cureus
|May 17, 2021
Summary
Systemic lupus erythematosus (SLE) can cause collapsing glomerulopathy (CG) and lupus nephritis, a rare kidney complication. This case highlights the diagnostic and management challenges of these concurrent conditions in lupus patients.
Area of Science:
- Nephrology
- Rheumatology
- Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disorder with diverse clinical manifestations.
- Kidney involvement in SLE, known as lupus nephritis, is a significant cause of morbidity and can lead to end-stage renal disease.
- Collapsing glomerulopathy (CG) is a severe form of kidney damage, and its association with SLE is infrequently reported.
Observation:
- This report details a rare case of a 47-year-old female diagnosed with both SLE-related collapsing glomerulopathy and lupus nephritis.
- The co-occurrence of these two distinct renal pathologies in a single patient is exceptionally uncommon.
- Literature review indicates fewer than 25 reported cases of concurrent SLE-related CG and lupus nephritis.
Findings:
- Biopsy-confirmed diagnosis revealed simultaneous collapsing glomerulopathy and lupus nephritis in the patient.
- The combination of CG and lupus nephritis presents unique pathological features.
- This case underscores the heterogeneity of lupus nephritis presentations.
Implications:
- The simultaneous presence of CG and lupus nephritis poses significant diagnostic and therapeutic challenges.
- Current clinical guidelines do not specifically address the management of patients with both conditions.
- Further research is needed to elucidate the pathogenesis and optimal treatment strategies for this rare SLE complication.
Related Concept Videos
01:20Renal Corpuscle
4.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
4.8K
01:24Nephrotic Syndrome I : Introduction
231
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
231
01:29Acute Kidney Injury II: Pathophysiology
465
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
465
01:10Nephrons
4.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
4.4K
01:28Chronic Kidney Disease III: Interprofessional Care
168
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
168
01:26Nephrotic Syndrome II : Assessment and Medical Management
52
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
52