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Native mitral valve endocarditis associated with KPC producing Serratia marcescens bacteremia successfully treated

Alwin Tilanus1, Francisco Mauricio Rincon2, Aura Maria Rivera2

  • 1Internist-Infectious Disease Specialist, Department of Infectious Diseases, Clinica Los Nogales, Calle 95 # 23 - 61, Bogotá, Colombia.

Idcases
|May 17, 2021
PubMed

Insights

The first case of mitral valve endocarditis caused by multi-resistant Serratia marcescens (KPC-producing) was reported. Treatment with ceftazidime-avibactam was successful after valve replacement.

Area of Science:

  • Infectious Diseases
  • Antimicrobial Resistance
  • Cardiology

Background:

  • Rising global prevalence of multidrug-resistant Gram-negative bacteria.
  • Endocarditis remains a significant cause of morbidity and mortality.

Observation:

  • First official case of native mitral valve endocarditis caused by multi-resistant Klebsiella Pneumonia Carbapenemase (KPC) producing Serratia marcescens.
  • Patient presented with symptoms consistent with severe infection.

Findings:

  • Successful treatment of Serratia marcescens endocarditis with ceftazidime-avibactam monotherapy.
  • Mitral valve replacement was a critical component of the treatment strategy.

Implications:

  • Highlights the emerging threat of KPC-producing Serratia marcescens in clinical settings.
  • Demonstrates the efficacy of ceftazidime-avibactam for treating challenging Gram-negative bacterial infections.
  • Underscores the importance of timely diagnosis and multidisciplinary management for endocarditis.
Keywords:
CarbapenemaseCeftazidime-avibactamEndocarditisKPCSerratia marcescens

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