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Management of tinea capitis in Israel: A comparative study.

Avner Shemer1, Aditya K Gupta1,2,3, Eran Galili1

  • 1Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Pediatric Dermatology
|May 17, 2021
PubMed
Summary

Terbinafine offers superior cure rates for pediatric tinea capitis compared to other oral antifungals. Prior topical steroid use negatively impacts treatment outcomes for this common fungal infection.

Keywords:
Trichopyhtondermatophytefungal infectionterbinafinetinea capitis

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Area of Science:

  • Dermatology
  • Mycology
  • Infectious Diseases

Background:

  • Tinea capitis is a prevalent fungal infection in Israel, frequently caused by Trichophyton tonsurans.
  • Understanding treatment efficacy is crucial for managing this common pediatric condition.

Purpose of the Study:

  • To assess the effectiveness of oral antifungal monotherapy for tinea capitis.
  • To evaluate the influence of prior topical treatments on achieving clinical or complete cure.

Main Methods:

  • Retrospective chart review of patients with confirmed tinea capitis.
  • Comparison of four oral antifungal regimens: terbinafine, itraconazole, fluconazole, and griseofulvin.
  • Analysis using generalized linear models (GLM) to determine cure rates.

Main Results:

  • Terbinafine demonstrated significantly higher odds of cure within 6 weeks in pediatric patients compared to itraconazole, fluconazole, or griseofulvin (OR=9.06, P=0.047).
  • Previous use of topical steroids was associated with lower cure rates within 8 weeks compared to prior topical antifungal use (OR=0.29, P=0.046).

Conclusions:

  • Terbinafine is a highly effective treatment for pediatric tinea capitis caused by T. tonsurans.
  • The study supports terbinafine's efficacy, aligning with existing literature on antifungal treatments.