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Updated: Nov 5, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Indirect Tertiary Alcohol Enantiocontrol by Acylative Organocatalytic Kinetic Resolution
Titouan Desrues1, Xueyang Liu1, Jean-Marc Pons1
1Aix Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, France.
Abstract:
The stereocontrol of tertiary alcohols represents a recurrent challenge in organic synthesis. In the present paper, we describe a simple, efficient, and indirect method to enantioselectively prepare tertiary alcohols through a chiral isothiourea catalyzed selective acylation of adjacent secondary alcohols. This transformation enables the kinetic resolution (KR) of easily prepared racemic diastereoenriched secondary/tertiary diols providing both monoesters and starting diols in highly enantioenriched forms (s-value >200).
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