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Gene for lipoamide dehydrogenase maps to human chromosome 7
G Otulakowski1, B H Robinson, H F Willard
1Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
Somatic Cell and Molecular Genetics
|July 1, 1988
Abstract:
The gene for lipoamide dehydrogenase (LD) has been assigned to human chromosome 7 based on filter hybridization analysis of genomic DNA from rodent-human somatic cell hybrids using a cDNA probe for human LD. No indication of multiple copies of the gene was found, in accordance with previous evidence that LD in the pyruvate, alpha-ketoglutarate, and branched chain alpha-ketoacid dehydrogenase complexes is genetically as well as biochemically identical.