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Pulmonary enteric adenocarcinoma.

Jiali Gong1, Ying Fan2, Hongyang Lu1

  • 1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, PR China; Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), 310022, PR China; Department of Thoracic Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), 310022, PR China; Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, 310022, PR China.

Translational Oncology
|May 17, 2021
PubMed
Summary
This summary is machine-generated.

Pulmonary enteric adenocarcinoma (PEAC) is a rare lung cancer mimicking colorectal cancer. Its unique mutations suggest targeted therapies may improve treatment outcomes for this challenging diagnosis.

Keywords:
DiagnosisImmunohistochemistryMutation analysisPEACPrognosis

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Pulmonary enteric adenocarcinoma (PEAC) is a rare non-small cell lung cancer (NSCLC) subtype.
  • PEAC shares pathological and clinical features with colorectal adenocarcinoma, complicating diagnosis.

Purpose of the Study:

  • To review the pathologic features, immunohistochemistry, mutation analysis, diagnosis, treatment, and prognosis of PEAC.
  • To highlight unique molecular and immune characteristics of PEAC.

Main Methods:

  • Literature review focusing on PEAC.
  • Analysis of pathologic, immunohistochemical (IHC), and mutation data.
  • Discussion of diagnostic and therapeutic strategies.

Main Results:

  • PEAC exhibits distinct mutation profiles: higher rates of Kirsten rat sarcoma viral oncogene (KRAS), human epidermal growth factor receptor-2 (HER2), and DNA mismatch repair (MMR) mutations.
  • Lower rates of epidermal growth factor receptor (EGFR) mutations are observed in PEAC compared to other lung adenocarcinomas.
  • Immunohistochemistry typically shows positive CDX-2, villin, and CK7 expression.

Conclusions:

  • PEAC presents diagnostic challenges due to similarities with metastatic colorectal adenocarcinoma.
  • Unique mutation profiles indicate potential for targeted therapies in PEAC treatment.
  • Further research into PEAC's specific characteristics is crucial for improving patient outcomes.