Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

Inflammatory Bowel Disease I: Ulcerative Colitis

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Humoral Immune Responses

Humoral Immune Responses

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

HLA genotype, clinical and immunofluorescence findings of 30 patients with type VII collagen antibody positive subepidermal bullous disease.

Clinical and experimental dermatology·2026

Same author

Low dose methotrexate and superpotent topical steroids in the management of bullous pemphigoid.

The British journal of dermatology·2026

Same author

Bringing back 'significance' to MGUS.

Rheumatology (Oxford, England)·2026

Same author

B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy.

Oncoimmunology·2026

Same author

Phenotypic, functional, prognostic and predictive significance of B-cell and antibody responses in human melanoma: a scoping review.

The British journal of dermatology·2026

Same author

Clinical correlation of anti-desmoglein antibody dynamics in pemphigus treated with rituximab.

Frontiers in immunology·2025

Same journal

Letter to the Editor: 'Life expectancy of UK physicians in the early 21st century: An analysis of 1,000 fellows from the Royal College of Physicians' Munk's Roll'.

Clinical medicine (London, England)·2026

Same journal

Finerenone Exposure and Ischemic Stroke in Patients with Type 2 Diabetes and Chronic Kidney Disease: A Propensity Score-Matched Cohort Study.

Clinical medicine (London, England)·2026

Same journal

Prevalence and predictive factors of chronic kidney disease among individuals with cardiometabolic risk factors: A multicenter cross sectional study, North East Ethiopia.

Clinical medicine (London, England)·2026

Same journal

Authors' response to Dr Lucy Williams' letter to the Editor: 'Life expectancy of UK physicians in the early 21st century: An analysis of 1,000 fellows from the Royal College of Physicians' Munk's Roll'.

Clinical medicine (London, England)·2026

Same journal

Resident doctor workforce wellbeing worldwide: lessons between the United Kingdom and Australia.

Clinical medicine (London, England)·2026

Same journal

Premature ventricular complexes.

Clinical medicine (London, England)·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 5, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Immunobullous disease.

Thomas J Tull¹, Emma Benton²

¹St John's Institute of Dermatology, London, UK.

Clinical Medicine (London, England)

|May 18, 2021

Summary

This summary is machine-generated.

This article explains immunobullous diseases, which are blistering skin conditions caused by antibodies attacking skin proteins. It covers the causes, symptoms, and treatments of common types.

Keywords:

bullous pemphigoid dermatitis herpetiformis epidermolysis bullosa aquisita immunobullous disorders pemphigus

More Related Videos

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Related Experiment Videos

Last Updated: Nov 5, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

Published on: September 7, 2022

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Area of Science:

Dermatology
Immunology
Pathology

Background:

Immunobullous diseases are a group of blistering skin disorders.
These conditions arise from pathogenic autoantibodies targeting specific skin proteins.
Disease presentation correlates with the structural characteristics of the target antigen.

Purpose of the Study:

To elucidate the pathogenesis of immunobullous diseases.
To describe the clinical features of common immunobullous disorders.
To outline current treatment strategies for these conditions.

Main Methods:

Review of existing literature on immunobullous diseases.
Analysis of pathomechanisms involving autoantibodies and skin structures.
Correlation of clinical morphology with underlying molecular targets.

Main Results:

Pathogenic antibodies binding to dermal or epidermal proteins cause blistering.
Distinct immunobullous disorders exhibit characteristic clinical and histological findings.
Understanding the target protein is key to classifying and managing these diseases.

Conclusions:

Immunobullous diseases represent a spectrum of autoimmune blistering conditions.
Accurate diagnosis relies on identifying the specific autoantibody and its target.
Effective management involves targeted therapies addressing the autoimmune response.