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Updated: Nov 5, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis: a brief overview.

Antony Raharja1, Satveer K Mahil1, Jonathan N Barker2

  • 1St John's Institute of Dermatology, London, UK.

Clinical Medicine (London, England)
|May 18, 2021
PubMed
Summary
This summary is machine-generated.

Psoriasis is a complex, lifelong skin condition affecting millions globally. Understanding its immune basis and comorbidities drives the development of targeted therapies for better patient outcomes.

Keywords:
biologicmultimorbidityplaquepsoriasispustular

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Area of Science:

  • Dermatology
  • Immunology
  • Genetics

Background:

  • Psoriasis is a chronic, heterogeneous skin disease with significant genetic influence, affecting 60 million worldwide.
  • It presents in various forms (plaque, guttate, pustular, etc.) and is linked to psoriatic arthritis and other comorbidities.
  • A multidisciplinary approach is essential due to its systemic associations, including cardiometabolic, hepatic, and psychological issues.

Purpose of the Study:

  • To provide an overview of psoriasis, encompassing its clinical heterogeneity, epidemiology, and pathophysiology.
  • To discuss the range of current and emerging treatment modalities for psoriasis.
  • To highlight the importance of understanding pathophysiology for developing targeted therapies.

Main Methods:

  • Literature review of psoriasis epidemiology, clinical presentation, and pathophysiology.
  • Summary of current treatment strategies, including topical, phototherapy, systemic, biologic, and small molecule inhibitors.
  • Discussion of advances in understanding disease mechanisms.

Main Results:

  • Psoriasis is an immune-mediated disease with a strong genetic component.
  • Multiple treatment options exist, ranging from conventional therapies to advanced biologics and small molecule inhibitors.
  • Advances in understanding psoriasis pathophysiology have enabled the development of highly effective, targeted treatments.

Conclusions:

  • Psoriasis requires a comprehensive management strategy due to its multifaceted nature and associated comorbidities.
  • Targeted therapies, informed by pathophysiological insights, represent a significant advancement in psoriasis treatment.
  • Continued research into the underlying mechanisms of psoriasis is crucial for further therapeutic innovation.