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The Future of Fat Grafting
1Department of Surgery, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Aesthetic Surgery Journal
|May 18, 2021
Summary
Autologous fat grafting (AFG) has evolved significantly since its 1893 origins. Future directions focus on optimizing techniques and exploring regenerative potential by deconstructing adipose tissue for diverse clinical applications.
Area of Science:
- Regenerative Medicine
- Plastic Surgery
- Tissue Engineering
Background:
- Autologous fat grafting (AFG) dates back to Neuber in 1893 for facial defects and Czerny in 1895 for breast reconstruction.
- Historical practices emphasized smaller fat lobules to prevent cyst formation.
- The scientific understanding and clinical applications of AFG have expanded considerably since its inception.
Purpose of the Study:
- To review the historical evolution of autologous fat grafting.
- To discuss current advancements and near-clinical translation of AFG techniques.
- To explore future directions in optimizing AFG for expanded clinical and regenerative indications.
Main Methods:
- Historical literature review of early autologous fat grafting cases.
- Discussion of current research trends and near-clinical translation in fat grafting.
- Exploration of future strategies including purified lipoaspirate and adipose tissue deconstruction.
Main Results:
- Early AFG pioneers like Neuber and Czerny established foundational techniques.
- Significant expansion in knowledge and application of AFG since the late 19th century.
- Emerging strategies involve purified lipoaspirate and selective use of adipose tissue components.
Conclusions:
- Autologous fat grafting continues to evolve with expanding clinical indications.
- Future research focuses on optimizing current techniques and exploring regenerative applications.
- Deconstructing adipose tissue offers novel avenues for regenerative medicine through AFG.
