Related Experiment Video
Updated: Nov 5, 2025

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
Published on: July 24, 2021
Towards Taming the Bugs to Improve the Drugs for Breast Cancer
1Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland. dsharma7@jhmi.edu.
Abstract:
The identification of microbial networks that are predictive of disease progression and response to therapy will not only increase our understanding of the connection between microbiota and breast cancer, but also pave the way for the development of novel microbiota-based therapeutic interventions. The study by Di Modica and colleagues points to the existence of specific microbiota in patients with HER2+ breast cancer that can influence their response to trastuzumab. This information can potentially be used to develop novel therapeutic regimens combining fecal microbiota transplant with standard cancer therapy.See related article by Di Modica et al., p. 2195.
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Biological Methods for Microbial Control
Methods for Controlling Microbial Growth
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers
Antibiotic Selection

