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Related Concept Videos

Drug Product Stability01:16

Drug Product Stability

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The long-term stability of drug products is critical to ensuring their quality, safety, and effectiveness over time. Stability directly influences a product's ability to maintain its intended characteristics, ensuring it performs as expected during its intended shelf life. Key attributes such as drug potency, impurities, dissolution, and other physicochemical measures of performance are tested to assess stability. These parameters indicate how well the product retains its quality over time and...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Key Techniques in Microbiology01:29

Key Techniques in Microbiology

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Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
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In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

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In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
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Related Experiment Video

Updated: Nov 5, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
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Insights on the Critical Parameters Affecting the Probiotic Viability During Stabilization Process and Formulation

Sharda Gurram1, Durgesh K Jha1, Devanshi S Shah1

  • 1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, 400019, India.

AAPS Pharmscitech
|May 19, 2021
PubMed
Summary

Probiotic formulations aim to deliver live microorganisms for health benefits. This review highlights critical processing factors affecting probiotic viability to ensure therapeutic efficacy.

Keywords:
critical process factorsmicroencapsulationprobioticsstabilizationviability

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Area of Science:

  • Microbiology
  • Pharmaceutical Sciences
  • Nutraceuticals

Background:

  • Probiotics, live microorganisms, offer health benefits for various conditions, including gut disorders and inflammation.
  • Effective probiotic therapy requires delivering a sufficient number of viable microorganisms, typically 10^8-10^9 CFU/g.
  • Probiotic viability is compromised by environmental and processing factors during formulation.

Purpose of the Study:

  • To review critical process parameters impacting probiotic viability during stabilization and formulation.
  • To emphasize the importance of understanding these factors for effective probiotic delivery.

Main Methods:

  • Literature review focusing on factors affecting probiotic viability in formulations.
  • Analysis of processing parameters such as temperature, humidity, and pressure.

Main Results:

  • Probiotic bacteria are sensitive to environmental and processing conditions, reducing viability.
  • Specific parameters like temperature and humidity significantly impact bacterial survival.

Conclusions:

  • Understanding and controlling critical process parameters are essential for maintaining probiotic viability.
  • Optimized formulation development ensures the delivery of efficacious doses of probiotics for therapeutic effects.