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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
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TAP AND INJECT VERSUS PARS PLANA VITRECTOMY FOR POSTPROCEDURAL ENDOPHTHALMITIS: A Meta-analysis
Parsa M Far1, Shanna C Yeung2, Pedram L Farimani2
1Department of Ophthalmology, Queen's University, Kingston, Ontario, Canada.
Retina (Philadelphia, Pa.)
|May 19, 2021
Summary
Intravitreal antimicrobial injection is as effective as prompt pars plana vitrectomy (PPV) for treating endophthalmitis. Both treatments offer comparable visual outcomes for post-surgical and post-injection infections.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Surgical Outcomes
Background:
- Endophthalmitis is a serious intraocular infection often occurring after eye surgery or injections.
- Prompt treatment is crucial to preserve vision and prevent further complications.
Purpose of the Study:
- To compare the visual outcomes of prompt pars plana vitrectomy (PPV) versus intravitreal antimicrobial injection for treating endophthalmitis.
- To determine the noninferiority of intravitreal antimicrobial injection compared to PPV.
Main Methods:
- A systematic review and meta-analysis of retrospective case series published between 2010 and 2020.
- Data from 1,355 eyes were analyzed, comparing visual outcomes (improvement of ≥2 lines and logMAR) between PPV and intravitreal antimicrobial injection.
- Methodological quality was assessed using the Cochrane ROBINS-I tool.
Main Results:
- Fifteen retrospective case series involving 1,355 eyes were included.
- No significant difference in visual outcome was observed between PPV and intravitreal antimicrobial injection.
- The relative risk of improving ≥2 lines was 1.04 (PPV vs. injection) and the mean difference in logMAR improvement was 0.04, with no statistical significance.
Conclusions:
- Intravitreal antimicrobial injection is noninferior to PPV for treating endophthalmitis.
- This finding applies to endophthalmitis occurring after cataract surgery, injections, and PPV procedures.
- Intravitreal antimicrobial injection represents a viable and effective initial treatment option.
