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Oxolinic acid in the trout: bioavailability and tissue residues
P Archimbault1, G Ambroggi, S Nicolas
1Departement of Toxicology and Pharmacology, Carros, France.
Annales De Recherches Veterinaires. Annals of Veterinary Research
|January 1, 1988
Summary
Oxolinic acid administered orally to trout maintained effective serum and tissue concentrations against target pathogens throughout treatment. A six-day withdrawal period is proposed based on residue tolerance levels in edible tissues.
Area of Science:
- Aquatic pharmacology
- Fish health management
- Veterinary medicine
Background:
- Oxolinic acid is an antibiotic used in aquaculture.
- Understanding its pharmacokinetics in fish is crucial for effective disease treatment and food safety.
- Trout are a significant aquaculture species.
Purpose of the Study:
- To determine the serum bioavailability and tissue elimination of oxolinic acid in trout.
- To assess if therapeutic concentrations are achieved and maintained.
- To establish a safe withdrawal period for oxolinic acid treatment.
Main Methods:
- Oxolinic acid was administered to trout via diet at 12 mg/kg/day for 7 days.
- Serum and tissue samples were analyzed using high-performance liquid chromatography (HPLC).
- Minimum Inhibitory Concentrations (MIC) for Aeromonas and Yersinia were considered.
Main Results:
- Sustained serum oxolinic acid concentrations exceeded the MIC for target pathogens throughout the treatment period.
- Therapeutic concentrations of oxolinic acid were also detected in fish tissues.
- A withdrawal time of six days is proposed based on a 0.05 ppm residue tolerance level in edible tissues.
Conclusions:
- Oral administration of oxolinic acid is effective in achieving therapeutic levels in trout serum and tissues.
- The proposed six-day withdrawal period supports safe consumption of trout following oxolinic acid treatment.
- This study provides valuable data for optimizing oxolinic acid use in aquaculture.