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Risk factors for cardiovascular mortality and melanoma-specific mortality among patients with melanoma: a SEER based

Alaa Ahmed Elshanbary1, Mohamed Sayed Zaazouee2, Mohamed Abdelmonem3

  • 1Faculty of Medicine, Alexandria University, Alexandria.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|May 19, 2021
PubMed

Insights

Older age, male sex, Black race, and certain melanoma subtypes increase cardiovascular mortality risk in melanoma patients. Conversely, being married and receiving treatments like chemotherapy, radiotherapy, or surgery are associated with lower cardiovascular death risk.

Area of Science:

  • Cardiovascular epidemiology
  • Oncology
  • Melanoma research

Background:

  • Cardiovascular disease (CVD) is a significant concern in melanoma patient outcomes.
  • Identifying risk factors for cardiovascular mortality is crucial for improving patient care.

Purpose of the Study:

  • To identify risk factors associated with cardiovascular mortality in a large cohort of melanoma patients.
  • To elucidate demographic, clinical, and treatment-related factors influencing cardiovascular death in melanoma survivors.

Main Methods:

  • Utilized data from the Surveillance, Epidemiology, and End Results (SEER) database for 194,503 melanoma patients.
  • Employed Person's chi-square test, Kaplan-Meier analysis, and Cox regression for statistical assessment.
  • Conducted univariate and multivariate analyses to determine significant risk factors.

Main Results:

  • Cardiovascular mortality affected 14.8% of the study cohort.
  • Higher cardiovascular-specific survival was observed in younger, female, married patients, and those with localized disease or who underwent surgery.
  • Increased risk of cardiovascular mortality was linked to older age (50-64 and ≥65 years), male sex, Black race, separation/widowhood, and lack of chemotherapy, radiotherapy, or surgery.

Conclusions:

  • Older age, male sex, Black race, and specific melanoma subtypes (nodular, lentigo maligna) are associated with higher cardiovascular mortality risk.
  • Marriage and treatments including chemotherapy, radiotherapy, and surgery appear to be protective factors against cardiovascular death in melanoma patients.
Abstract

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