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Rectal diclofenac versus high-dose rectal acetaminophen in children: A randomized clinical trial

Houman Hashemian1, Marzie Fallah Khodadoost1

  • 1Pediatric Diseases Research Center , Guilan University of Medical Sciences, Rasht, Iran.

Caspian Journal of Internal Medicine
|May 20, 2021
PubMed

Insights

Diclofenac suppositories were more effective than high-dose acetaminophen suppositories in reducing fever in children aged 1-6 years. Both medications significantly lowered temperature, but diclofenac showed a greater reduction in pediatric fever.

Area of Science:

  • Pediatrics
  • Pharmacology
  • Clinical Medicine

Background:

  • Fever is a prevalent symptom in children admitted to healthcare facilities.
  • This study addresses the common clinical challenge of managing pediatric fever.

Purpose of the Study:

  • To compare the antipyretic efficacy of diclofenac and high-dose acetaminophen suppositories.
  • To evaluate fever reduction in children aged 1 to 6 years.

Main Methods:

  • A double-blind clinical trial involving 90 children (1-6 years old).
  • Participants received either high-dose acetaminophen (30 mg/kg) or diclofenac (1 mg/kg) suppositories.
  • Rectal temperature was measured at baseline, 1 hour, and 3 hours post-administration.

Main Results:

  • Diclofenac group showed a significantly greater temperature reduction (1.76±0.95°C) compared to the acetaminophen group (1.26±0.49°C).
  • The difference in temperature reduction between the two groups was statistically significant (P=0.019).

Conclusions:

  • Both acetaminophen and diclofenac suppositories effectively reduce fever in children.
  • Rectal diclofenac demonstrates a superior antipyretic effect compared to rectal acetaminophen in this pediatric population.
Abstract

Keywords:
AcetaminophenDiclofenacFeverRectalSuppository

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