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Updated: Nov 5, 2025

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Published on: April 13, 2011
Exogenous insulin antibody syndrome treated with plasma exchange after an incomplete response to immunosuppressive
Yuan Zhuang1, Xudong Wei2,3, Yang Yu1
1Department of Blood Transfusion, First Medical Center of Chinese PLA General Hospital, Beijing, China.
Abstract:
A 43-year-old man with a 23-year history of type II diabetes presented with uncontrolled hyperglycemia with frequent episodes of ketoacidosis. He was diagnosed with exogenous insulin antibody syndrome, and received high-dose methylprednisolone to treat insulin resistance. Ketoacidosis relapsed 2 years later, and the patient showed an incomplete response to glucocorticoids. We decided to administer therapeutic plasma exchange, which resulted in rapid lowering of the daily insulin requirement and improved glycemic control.
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