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Tau heckles speckles: A pathogenic mechanism in tauopathy?
Erica L Gorenberg1, James Shorter1
1Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
Neuron
|May 20, 2021
Abstract:
Protein aggregates can sequester RNA in neurodegenerative disease, but the exact RNAs sequestered by tau inclusions have remained uncharacterized. In this issue of Neuron, Lester et al. (2021) begin to identify these RNAs and reveal related perturbations in nuclear speckles.
