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Updated: Aug 10, 2026
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
Thermoresponsive Pluronic based microgels for controlled release of curcumin against breast cancer cell line
Anuja S Kulkarni1, Savita R Tapase1, Kisan M Kodam1
1Department of Chemistry, Savitribai Phule Pune University, (Formerly, University of Pune), Pune, 411007, India.
Abstract:
We developed here stimuli responsive curcumin loaded microgels based on Pluronic F-127. These microgels were prepared using coupling reaction between the amine modified Pluronic and EDTA. The microgel exhibited the affinity for hydrophobic drug, curcumin and showed pH as well as temperature-dependent release. Furthermore, the cytotoxicity study demonstrated dose-dependent inhibition of MDA-MB-231 cell growth with the most effective IC50 value (3.8 ± 0.2 μg mL-1 after 24 h). Based on these findings, the fabricated curcumin loaded microgels offered additional advantages over conventional drug therapies for treatment of cancer.
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