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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

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Resistance to Antifungal Drugs

Ronen Ben-Ami1, Dimitrios P Kontoyiannis2

  • 1Infectious Diseases Department, Sackler School of Medicine, Tel Aviv University, Tel Aviv Sourasky Medical Center, 6 Weizmann, Tel Aviv 64239, Israel.

Infectious Disease Clinics of North America
|May 21, 2021
PubMed

Insights

Pathogenic fungi develop drug resistance through genetic adaptability and stress responses. Understanding these mechanisms is crucial for developing new treatments for fungal infections.

Area of Science:

  • Mycology
  • Molecular Biology
  • Antimicrobial Resistance

Background:

  • Pathogenic fungi exhibit significant genetic plasticity.
  • Fungal resistance to antifungal drugs is a growing clinical concern.
  • Homeostatic responses to environmental stress contribute to fungal adaptability.

Purpose of the Study:

  • To critically review the molecular mechanisms of antifungal resistance in pathogenic fungi.
  • To discuss cellular adaptations and contributing factors to antifungal resistance.
  • To suggest future directions for translational and clinical research.

Main Methods:

  • Comprehensive literature review of molecular mechanisms.
  • Analysis of genetic and cellular adaptations.
  • Discussion of contributing factors to resistance.

Main Results:

  • Pathogenic fungi employ diverse mechanisms to resist antifungal drugs.
  • Genetic plasticity and homeostatic responses are key drivers of resistance.
  • Understanding these mechanisms is vital for clinical applications.

Conclusions:

  • Enhanced understanding of antifungal resistance is needed.
  • Development of better detection tools and treatment strategies is a priority.
  • Future research should focus on translational and clinical applications to combat refractory mycoses.
Keywords:
Animal modelsAspergillusCandidaCryptococcusFungalMechanismsResistance

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