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[Skin lesions in children during the first wave of the SARS-CoV-2 pandemic]
Begoña Carazo Gallego1, Laura Martín Pedraz1, Rocío Galindo Zavala2
1Unidad de Infectología Pediátrica, UGC Pediatría, Hospital Regional Universitario de Málaga, Málaga, España.
Insights
Children with chilblain-like or vesicular skin lesions may have had prior contact with SARS-CoV-2, the virus that causes COVID-19. Further investigation is needed to understand this association in pediatric cases.
Area of Science:
- Pediatric Dermatology
- Infectious Diseases
- Viral Exanthems
Background:
- COVID-19 presents with diverse clinical symptoms, including skin manifestations.
- Understanding the link between pediatric skin conditions and SARS-CoV-2 is crucial.
Observation:
- A multicenter, cross-sectional study included 62 children with skin manifestations.
- SARS-CoV-2 infection was assessed via PCR and serology.
Findings:
- Children with positive SARS-CoV-2 antibodies were more likely to have chilblains or vesicular lesions (66.7%) compared to those without (24.5%).
- Generalized, urticarial, and maculopapular rashes were more common in antibody-negative children (37.7%), often with other identified pathogens.
- No significant differences in autoantibody positivity were observed between groups.
Implications:
- Chilblain-like and vesicular lesions in children may indicate previous SARS-CoV-2 exposure.
- These findings aid in diagnosing and managing pediatric skin conditions potentially related to COVID-19.
Background:
Cutaneous manifestations have been included in COVID-19 patients' clinical spectrum. Our objective was to determine the association between skin lesions in children and SARS-CoV-2 infection, analyzing others possible infectious/autoimmune etiologies.
Material And Methods:
Observational, multicenter, cross-sectional study, about children with skin manifestations from April to May 2020. The diagnosis of SARS-CoV-2 was performed by PCR in nasopharyngeal exudate and/or presence of antibodies by serology.
Results:
Sixty-two children were included, 9 (14.5%) presented positive antibodies to SARS-CoV-2, with no positive PCR to SARS-Cov-2 in those patients in whom it was made. Patients with positive serology to SARS-CoV-2 presented chilblains and/or vesicular-bullous skin lesions more frequently (66.7% vs. 24.5%, p=0.019). Generalized, urticarial and maculopapular rash was more common in patients with negative antibodies (37.7 vs. 0%, p=0.047), others pathogens were isolated in 41.5% of these patients. There were no significant differences in the positivity for autoantibodies between both groups.
Conclusion:
In our study, the presence of chilblains-like and/or vesicular lesions were significantly related to SARS-CoV-2 previous contact.
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