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Progress in Borneol Intervention for Ischemic Stroke: A Systematic Review.

Yong Li1, Mihong Ren1, Jiajun Wang1

  • 1College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Frontiers in Pharmacology
|May 21, 2021
PubMed
Summary
This summary is machine-generated.

Borneol, a natural compound, offers neuroprotection against ischemic stroke by improving blood flow and reducing neuronal damage. It aids in brain repair and regeneration, offering a multi-faceted therapeutic approach.

Keywords:
D-borneolDL-borneolL-borneolcascade reactionischemic strokeneuroprotection

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Borneol is a terpene with demonstrated neuroprotective effects, particularly in traditional Chinese medicine for stroke.
  • Existing research on borneol's efficacy in ischemic stroke lacks systematic review.
  • This study systematically evaluates borneol's neuroprotective actions across different phases of experimental ischemic stroke.

Purpose of the Study:

  • To systematically review and analyze the neuroprotective effects of borneol in experimental ischemic stroke.
  • To elucidate the mechanisms of action of borneol at various stages of cerebral ischemia.
  • To provide a comprehensive overview of borneol's therapeutic potential for stroke treatment.

Main Methods:

  • A systematic literature search was conducted across major biomedical databases for studies published in the last 20 years.
  • Included animal and cell-based research on borneol's effects on ischemic stroke.
  • Meta-analysis of key indicators from in vivo experiments was performed.

Main Results:

  • Borneol demonstrates efficacy in preventing and treating nerve injury in ischemic stroke.
  • Mechanisms include improved cerebral blood flow, reduced excitotoxicity, controlled calcium overload, and antioxidant effects in the acute stage.
  • In subacute stages, borneol mitigates blood-brain barrier damage, modulates inflammation, and prevents neuronal death.
  • In later stages, borneol promotes neurogenesis and angiogenesis.

Conclusions:

  • Borneol exerts multi-mechanistic neuroprotection against cerebral ischemia, promoting brain tissue repair and regeneration.
  • Its broad therapeutic action avoids the limitations of single-target drugs.
  • Borneol can enhance the blood-brain barrier penetration of other drugs, leading to synergistic effects.