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Hyaluronic Acid Reduces Fibrosis in a Rabbit Model of Urethral Anastomosis
Eliseo Portilla-de Buen1, Juan Pablo Ramirez-Contreras2, Jonathan Matias Chejfec-Ciociano2
1Surgical Research Division, Western Biomedical Research Center, Western Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, México.
Research and Reports in Urology
|May 21, 2021
Summary
Hyaluronic acid (HA) treatment significantly reduced fibrosis in a rabbit urethral anastomosis model. This finding suggests HA may be a promising therapy for preventing urethral stricture recurrence.
Area of Science:
- Regenerative Medicine
- Urology
- Biomaterials Science
Background:
- Urethral stricture, a condition marked by fibrosis, frequently recurs after treatment.
- Current therapies for urethral stricture have limited long-term success rates.
- Fibrosis following urethral anastomosis is a key factor in stricture development.
Purpose of the Study:
- To evaluate the efficacy of hyaluronic acid (HA) in mitigating fibrosis.
- To assess HA's potential in preventing urethral stricture formation in a rabbit model.
Main Methods:
- A rabbit model of urethral anastomosis was established.
- Hyaluronic acid (HA) was applied to the anastomosis site in the experimental group (n=10).
- Sterile saline was applied to the control group (n=10), with measurements taken after 12 weeks.
Main Results:
- Hyaluronic acid (HA) treatment significantly reduced collagen fiber band thickness (275.9 ± 62.3 μm vs. 373.4 ± 44.3 μm; p=0.001).
- Urethral lumen diameter was significantly larger in the HA group (2575 ± 167 μm vs. 2382 ± 214 μm; p=0.04).
- Inflammatory infiltrate levels were comparable between groups.
Conclusions:
- Hyaluronic acid (HA) effectively reduced fibrosis at the urethral anastomosis site in rabbits.
- These findings support further investigation into HA for treating urethral stricture.
- HA demonstrates potential as a therapeutic agent to prevent urethral stricture recurrence.
