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Correlation between Insulin-Like Growth Factor I and Skeletal Maturity Indicators
Julia Carelli1,2, Camila Mattos1, Nathaly D Morais1
1Positivo University, Curitiba, Paraná, Brazil.
Global Pediatric Health
|May 21, 2021
Summary
Orthodontic patients' skeletal maturity indicators, including hand-wrist (SMI) and cervical vertebrae maturation (CVM) stages, show a strong correlation. Insulin-like growth factor 1 (IGF-1) demonstrated only a moderate association with these growth indicators.
Area of Science:
- Orthodontics
- Pediatric Dentistry
- Growth and Development
Background:
- Accurate assessment of skeletal maturity is crucial for effective orthodontic treatment planning.
- Various indicators, such as hand-wrist (SMI) and cervical vertebrae maturation (CVM) stages, are used to determine growth potential.
- Understanding the correlation between these indicators and biochemical markers like IGF-1 can refine treatment timing.
Purpose of the Study:
- To evaluate the correlation between skeletal maturation indicators (SMI and CVM) and serum IGF-1 levels in orthodontic patients.
- To determine the reliability of SMI and CVM in assessing skeletal maturity in Class II patients aged 10-16 years.
Main Methods:
- Cross-sectional study of 37 Class II orthodontic patients (17 males, 20 females) aged 10-16 years.
- Evaluation of hand-wrist radiographs using the 11-stage skeletal maturation indicator (SMI) technique.
- Assessment of lateral cephalometric radiographs using the 6-stage cervical vertebrae maturation (CVM) technique.
- Quantification of serum IGF-1 levels and statistical analysis using Pearson correlation and Shapiro-Wilk tests.
Main Results:
- A strong positive correlation was found between SMI and CVM stages in the total sample (r=0.864) and by gender.
- IGF-1 levels showed a moderate correlation with both SMI (r=0.793 for females, r=0.753 for males) and CVM stages.
- The findings indicate high consistency between the two radiographic skeletal maturity assessment methods.
Conclusions:
- Hand-wrist and cervical vertebral maturation stages are strongly correlated, confirming their utility in assessing skeletal maturity.
- Serum IGF-1 levels exhibit a moderate correlation with skeletal maturity indicators, suggesting it may offer supplementary, but not primary, information for treatment timing.
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