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Updated: Nov 4, 2025

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Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
Published on: October 15, 2019
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Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity
Akinobu Z Suzuki1, Taichi Sakano1, Hirona Sasaki1
1Department of Biomolecular Science, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510, Japan. furuta@biomol.sci.toho-u.ac.jp.
Abstract:
We designed a new caging group that can be photoactivated only in the presence of a non-endogenous enzyme when exposed to 405 nm light. Because cells or tissues can be genetically tagged by an exogenously expressed enzyme, this novel method can serve as a strategy for adding targeting abilities to photocaged compounds.

