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Updated: Nov 4, 2025

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
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GLUT1 biological function and inhibition: research advances

Shuang Cao1, Yongshou Chen1, Yixin Ren1

  • 1Key Laboratory of Green Chemical Engineering Process of Ministry of Education, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, PR China.

Future Medicinal Chemistry
|May 21, 2021
PubMed

Insights

Glucose transporters (GLUT) fuel cell growth. GLUT inhibitors are explored to block tumor cell energy, focusing on GLUT1

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Background:

  • Glucose transporters (GLUT) are crucial for cellular metabolism, supplying nutrients for growth and proliferation.
  • Tumor cells often exhibit altered glucose metabolism, making them reliant on GLUT for energy.
  • Targeting tumor cell energy intake is a significant area of cancer research.

Purpose of the Study:

  • To review the structure and function of GLUT1.
  • To delineate structural and functional differences among GLUT1-4 transporters.
  • To explore the link between GLUT1 and tumor development and discuss GLUT1 inhibitors for potential cancer therapies.

Main Methods:

  • Literature review and synthesis of existing research on GLUT transporters.
  • Analysis of structural and functional data for GLUT1-4.
  • Examination of studies linking GLUT1 expression to tumor progression.

Main Results:

  • GLUT1 is a primary glucose transporter involved in supplying energy to cells, including tumor cells.
  • Significant structural and functional variations exist across GLUT1-4 isoforms.
  • Elevated GLUT1 expression is associated with various types of cancer development and progression.

Conclusions:

  • GLUT1 plays a critical role in fueling malignant tumors.
  • Understanding GLUT1 structure, function, and its role in cancer is essential for developing targeted therapies.
  • GLUT1 inhibitors represent a promising strategy for blocking tumor energy supply and treating cancer.
Keywords:
GLUT1HCCcancerinhibitor

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