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Updated: Nov 4, 2025

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
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Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension

Published on: April 11, 2016

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Arterial hypertension

Sofie Brouwers1, Isabella Sudano2, Yoshihiro Kokubo3

  • 1Department of Cardiology, Cardiovascular Center Aalst, OLV Hospital Aalst, Aalst, Belgium; Department of Experimental Pharmacology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.

Lancet (London, England)
|May 21, 2021
PubMed

Insights

Arterial hypertension is a major global health issue with poor control rates. Improved screening, diagnosis, and treatment strategies, including lifestyle changes and new therapies, are crucial for better patient outcomes.

Area of Science:

  • Cardiology
  • Public Health

Background:

  • Arterial hypertension significantly contributes to the global disease burden, yet effective disease control remains a challenge.
  • Current hypertension diagnosis relies on office blood pressure, but out-of-office measurements are recommended for confirmation.

Purpose of the Study:

  • To review current understanding and management strategies for arterial hypertension.
  • To highlight the gap between hypertension's controllability and actual patient outcomes.

Main Methods:

  • Review of current hypertension guidelines and therapeutic options.
  • Discussion of pharmacological and device-based treatment approaches.
  • Emphasis on lifestyle modifications in hypertension management.

Main Results:

  • First-line pharmacological treatments include ACE inhibitors/ARBs, calcium channel blockers, and diuretics, often as single-pill combinations.
  • Spironolactone is a recommended fourth-line agent, and device-based therapies like renal denervation are emerging.
  • Despite being controllable, awareness, treatment, and control rates for hypertension remain low.

Conclusions:

  • Arterial hypertension requires urgent improvements in screening, diagnosis, treatment, and follow-up processes.
  • Enhanced patient management strategies are essential to improve control rates and reduce the global burden of hypertension.

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