Related Experiment Video
Updated: Nov 4, 2025

Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension
Published on: April 11, 2016
Arterial hypertension.
Sofie Brouwers1, Isabella Sudano2, Yoshihiro Kokubo3
1Department of Cardiology, Cardiovascular Center Aalst, OLV Hospital Aalst, Aalst, Belgium; Department of Experimental Pharmacology, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium.
Arterial hypertension is a major global health issue with poor control rates. Improved screening, diagnosis, and treatment strategies, including lifestyle changes and new therapies, are crucial for better patient outcomes.
Area of Science:
- Cardiology
- Public Health
Background:
- Arterial hypertension significantly contributes to the global disease burden, yet effective disease control remains a challenge.
- Current hypertension diagnosis relies on office blood pressure, but out-of-office measurements are recommended for confirmation.
Purpose of the Study:
- To review current understanding and management strategies for arterial hypertension.
- To highlight the gap between hypertension's controllability and actual patient outcomes.
Main Methods:
- Review of current hypertension guidelines and therapeutic options.
- Discussion of pharmacological and device-based treatment approaches.
- Emphasis on lifestyle modifications in hypertension management.
Main Results:
- First-line pharmacological treatments include ACE inhibitors/ARBs, calcium channel blockers, and diuretics, often as single-pill combinations.
- Spironolactone is a recommended fourth-line agent, and device-based therapies like renal denervation are emerging.
- Despite being controllable, awareness, treatment, and control rates for hypertension remain low.
Conclusions:
- Arterial hypertension requires urgent improvements in screening, diagnosis, treatment, and follow-up processes.
- Enhanced patient management strategies are essential to improve control rates and reduce the global burden of hypertension.
More Related Videos
09:37Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
Published on: August 1, 2018
09:23Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
Published on: February 11, 2017
Related Concept Videos
Hypertension I: Introduction
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Hypertension and Regulation of Blood Pressure
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Alterations in Blood Pressure
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...